You may like to check again that you have entered all the details correctly with city, state, and zip code. Having a P.O. Box address should not cause the return to be rejected. I tried entering a P.O. Box address but didn't get any diagnostic, not to say it won't cause a rejection in the end.
AFAIK, the IRS matches EIN but not street address.
What error message are you getting exactly and where is that showing up?
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