More specifically, I'm trying to understand where is the program itself stored and launched from: work station or server, for concurrency considerations? And instead of everyone being Admin, did you try "run as Admin" for the installs, for all users? That can isolate them to only those functions, and protect your server access controls.

"We used ProSeries last year (2021 version) and didn't experience this problem"

I don't know if it matters to your install/network, but you know that 2022 is now 64-bit. Did you check if you have a compatibility issue?