Let's fix how you stated this part: "CX has 1 1099 employee and 2 that he issues w2 ."

I don't know what "CX" is. Your taxpayer has a business with 1 independent contractor providing goods and/or services to the business, as their own business. And, your taxpayer has 2 employees on payroll.

If that 1099 person is an "employee" then they are misclassified as a 1099 independent contractor and should have been on payroll.

It helps to state it correctly, as the taxpayer needs to understand if they have this correctly or have a problem.

"Where to enter these with the tax WH info?"

You only withhold for income tax on an independent contractor because they notified you that they are subject to Backup Withholding, which means the IRS no longer trusts that this person is honestly paying their own liability to the IRS in a timely manner.

There should not have been Medicare or Social Security withholding for that 1099 person.

And their withholding is not reported the same as the 2 employees' withholding. Employees are reported 941/944. Backup withholding on the 1099 is reported on 945 and then as part of the 1096 ("cover sheet").

The 1099 person is not being paid Wages.

The payroll people and the 1099 person have withholding as a diversion of their pay. It isn't reported on the tax return for the business as an additional expense. It's already part of Gross expense for the labor (payroll or contractor).

For the 2 employees, the business will have Employer expense for the Employer share of Social Security, Medicare, and Unemployment.

There is no Unemployment paid by this business (who is not the employer) for contractors.

Hope that helps sort out this confusion.