Did they have estimates paid in that weren't paid evenly during the year?

Yes paid unevenly due to Long Term Cap Gains coming unevenly during the year.  Though the safe harbor would alleviate any penalty.  Do I suppress 2210 and see if IRS bills me?  Looks like Proconnect won't apply the safe harbor.   I use Proconnect for my personal return.  Thanks for your quick reply.

110% of the prior year tax safe harbor only works if the payments are made evenly. You want to do the annualization method.

Oh joy!  Thanks for your input.