@JeromeLeventhal I tried this with Windows Security (the only security measure on my computer) and it did not work for me. I have tried multiple different things within Windows Security seeing if any would work, and no luck. I am still unable to save without doing the File > Save As workaround. I even tried turning off real time scanning for a brief time to see if that would remedy it, but no. I'm curious if there is a correlation with this problem and OneDrive - though it likely doesn't fit the problem for everyone else, we recently (last 3-4 weeks or so) turned this off on our office computers because we were finding that personal C drive files were showing up as visible on other computers around the office! NOT a fan of OneDrive!

@jerrybittick I believe the idea is to File > Save As and replace the original file so that you don't have multiple files for the same tax return. It's just an extra step in the save process that is frustrating, but if it works for now that is something! I do agree that this needs to be remedied somehow. Our firm is fortunate to have Windows 10 on another 2 machines in the office, otherwise we'd be out of luck and unable to e-file 2021 returns, which are funnily enough still flowing in...