I am having the same problem.  It happened with a problem doing product updates.  Now I get the error message: Proseries has detected an issue with a Microsoft.NET Framework File.

I tried an uninstall of the Microsoft.net files on Control Panel, Programs Files, Turn Microsoft Features on/off.  I rebooted, reinstalled and still get the same error.  I also uninstalled Proseries and reinstalled.  Help! 🙂