Did you prepare the 2021 return? If so, open it and use SAve As and save it as WhatIf Estimate...enter the sale as if it happened in 2021 and see what kind of gain she ends up with for Fed and CA, then you'll have a good idea of how much to pay in estimated taxes.  You may have to backdate your purchase date so that the time frame for ownership is correct since youre using 2021 program instead of 2022.

Be sure to uncheck the EF boxes on that Saved As copy, or you'll see red errors in the EFCenter for a duplicate SSN.