I have successfully used DocuSign with dozens of MD returns without any problems.  So long as there are no errors on the return, the form will populate on the esignature dashboard.  Please be sure your MD return is marked "Return Ready for Efile". 

For those MD returns impacted by the issue discussed in this thread which cannot be finalized for DocuSign through ProSeries, I have been successful signing directly into DocuSign and manually uploading any form that I want signed.  It's a great site, and includes everything that has been processed through ProSeries.

Good luck!

Mike