Hi @bk23, I can't give you a concrete answer, but if ProSeries is working in Safe Mode, that indicates there's some other program interfering with ProSeries when running Windows normally. 

Have you tried closing as many programs as possible and then trying to run ProSeries?

If you're comfortable making changes to your system, you can also try disabling various startup programs in Task Manager (in the Startup tab) to see if that helps: