Every now and then I get a window that asks me if I want to lose it permanently, I choose YES, but it comes back after the next update....I think were stuck with it.

Easy - Uninstall ProSeries.

As a side note, if ProSeries is an advertisement-based software, shouldn't that mean it is FREE?

Intuit - are you paying attention??  We pay a lot for this software and don't want to be force-fed your advertisements trying to persuade us to spend more money.  Give us the option to MAKE IT GO AWAY PERMANENTLY the first time it displays!!

Hi @SmallTaxFirm Thank you for the feedback. We've shared it with the appropriate teams. Are you able to send a screenshot of the specific pop-up? 

Its the E signature purchase window that slides out from the right side of the screen and covers a third of the EF Center Homebase Window.   After closing it 20+ times, it eventually gives me a window that asks if I want to close it permanently, I choose YES, but after an update it always comes back.

I found that a stick of dynamite does solve the issue, but it really makes a mess out of your computer in the process.  The window is like cancer, it might go into remission, but it always comes back.